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desvenlafaxine will enhance the amount or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) reduce the CYP2D6 substrate dose by nearly 50%; no dosage adjustment necessary with desvenlafaxine doses seven consecutive times immediately ju